On ESPN.com there are the results for the computer simulations they use to predict the spread/winners for the games.
Buffalo is winning 53% of the sims, with the Seahawks +.5 in the spread. The computers also predict Hasselbeck to out-perform Edwards, but Lynch out-gaining the Jones/Morris combination. The Bills averaged 20.3 points/sim and the Seahawks garnered 19.9 points/sim.
Now, these computers have been pretty accurate in the past... so take this stuff for what it's worth. It all sounds about right. I see both teams scoring about 1 TD and the one that makes the most field goals wins. I watched Seattle in the preseason and Holmgren really has an awesome scheme, they really make up for their lack of offensive talent (let's be honest, Seattle is loaded with marginal talent, offensively... and that includes Mo Morris). It almost seems inevitable that the Bills will be dinked and dunked all day long with the occasional post or seem route being completed. However, when teams use this strategy against Jauron, they tend to settle for a lot of field goals (bend but don't break... whatever). Let's hope Schizzle takes advantage of Seattle's pass-rushing prowess with a lot of screens, draws, and quick hitters.
Don't be surprised, Bills fans, if Buffalo straight up cleans Seattle's clock. Matt Hasselbeck is banged up/rusty and his receivers are young and inconsistent. We could see him struggle to find open receivers and hold onto the football too long (or just long enough to get smacked). They will probably be leaning on their running game heavily and if Buffalo is stout like they were in the preseason... it could be a very long day in Buffalo and an even longer flight all the way back to the West Coast.