NFL.com's Jason La Canfora is reporting this morning that the Bills are "not overly inclined to trade up for a QB." That would indicate Jimmy Clausen and possibly Colt McCoy are highly unlikely possibilities for the Bills as the second round gets under way tonight.
La Canfora suggests the Bills may go with a left tackle at No. 41 and select a quarterback in a later round.
A separate report by WGR's Jeremy White says that it's "very unlikely the Bills go QB in round 2," which backs up La Canfora's report.
As always, we'll update as the day continues.