After seeing Tebow basically run through the Jets defense, I believe the most powerful weapon the Bills have against the Jets is to put Brad Smith in a conventional formation—by that I mean not the wildcat—and using him in exactly the same way the Broncos are using Tebow

My dramatically oversimplified view, this is why it will work:

it clears out the backers with coverage requirements,
forces the d-line to commit to a pass rush,
that creates holes and creases.

Essentially, the Jets defense played their scheme, which against a QB like Tebow—and similarly I would hope Smith—amounts to overkill with regard to pass defense.  The Bills have a weapon that exploits this apparent weakness the Broncos just exposed.

The key, as it was in this Thursday night game, is being a physical runner.  I think Brad Smith passes the eyeball test there.