Byrd notched an interception on both Arizona quarterbacks. The first was in the fourth quarter off starter Kevin Kolb in Bills territory with Arizona threatening. In overtime, Byrd intercepted back-up John Skelton and returned it to the six-yard line, setting up Rian Lindell's kick to win the game by a 19-16 tally. He also added four tackles during the game.
The game was the fourth multi-interception game of Byrd's career. The fourth-year safety is the first Bills defender to earn the honor since George Wilson in Week 5 of 2011.
Byrd is scheduled to be a free agent following the 2012 season but talks have been ongoing with his agent since the offseason. He was selected in the second round of the 2009 NFL draft.