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The Buffalo Bills haven't won a game in the Pacific Time Zone since 2004, when they beat the San Francisco 49ers 41-7. Since then, they're 0-4 on the left coast, losing by an average score of 41-14.
The Buffalo Bills don't travel to the west coast very often to play regular season football games, but they'll do so for the next two weeks, when they take on the San Francisco 49ers and Arizona Cardinals in back-to-back contests.
Buffalo hasn't won a game three time zones to the left since 2004 - the year Mike Mularkey, Drew Bledsoe and the No. 2 defense in the NFL almost took the team to the playoffs - when, in Week 16, they trounced the 49ers 41-7 before a Week 17 loss derailed their playoff hopes.
Since that 2004 season, the Bills have only played four games on the west coast. Two of them occurred the following year in 2005: Buffalo was crushed 38-17 by the Oakland Raiders in Week 7, then 48-10 by the San Diego Chargers a month later. In 2008, the Bills migrated west to get dominated by the Arizona Cardinals, 41-17, bringing an end to their 4-0 start that year. Finally, just last season, the Bills were blown out by the Chargers again, 37-10, the sixth in a seven-game losing streak.
So, yeah: in their last four games on the left coast, the Bills have been defeated by an average score of 41-14.
Their next two opponents in the Pacific Time Zone, San Francisco and Arizona, are a combined 7-1 on this very young 2012 season. The 49ers, coming off of a trip to the NFC Championship Game in 2011, have what most consider to be the most talented defense in the NFL, while Arizona is off to a 4-0 start thanks largely to their stout and opportunistic defense. The Bills have an uphill battle in front of them not just in terms of keeping their playoff hopes alive and the morale of the fan base above water, but in ending their left-coast futility, as well.