Buffalo Bills (2-2) at San Francisco 49ers (3-1)
Sunday, October 7 at 4:25 PM ET
Candlestick Park, San Francisco, CA

Bills inactives: QB Tarvaris Jackson, RB Johnny White, OT Cordy Glenn, OG Kraig Urbik, DT Spencer Johnson, LB Kirk Morrison, SS Delano Howell

The most popular angle being taken with regard to the Buffalo Bills' first four games this regular season: they've beaten two of the league's worst teams, and they've been manhandled by two division rivals that routinely manhandle them. A popular angle to take for every season in recent memory? Buffalo beats the bad teams and can't beat the good ones.

Well, the Bills have a chance to beat a good team this afternoon when they take on the San Francisco 49ers. Jim Harbaugh's crew isn't just a good team; they're considered one of the most talented teams in the league, and are as legitimate a Super Bowl contender as you're likely to find in early October.

This is your open thread for the first half of today's Bills versus 49ers game. It's time for Buffalo to decide what their response will be when they get kicked in the teeth - because San Francisco will do precisely that today. Will the Bills kick back and play competitive ball, or will they roll over and die as they did a week ago? Time will tell. Until then, our battle cry: go Bills!