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Not only did the Buffalo Bills get blown out by San Francisco in Week 5, but their injury situation looks quite bleak entering a huge Week 6 matchup with Arizona.
Coming off of two consecutive blowout losses, the Buffalo Bills are not only reeling on the gridiron, they're struggling in the trainer's room, as well. When the team takes on the Arizona Cardinals this Sunday, they could be without as many as four starters - and they're particularly decimated along the offensive line.
Let's start up front, where left tackle Cordy Glenn and right guard Kraig Urbik both missed Sunday's loss to San Francisco with high ankle sprains. Neither one made the trip to the west coast with Buffalo, and both are already considered out for the Arizona game. They will be joined by reserve guard/center Colin Brown, whose injured hamstring suffered last week has already caused him to be ruled out by head coach Chan Gailey.
Chad Rinehart, the top interior line reserve, did not start against San Francisco with a calf injury. He was pressed into duty when Brown went down, but later left the game and was replaced at right guard by reserve tackle Sam Young. Rinehart will not practice Wednesday and is anything but a lock for Sunday, but Gailey at least sounded optimistic that the Bills might not have to roll with Young at right guard by choice.
Jairus Byrd is in the same boat as Rinehart from a practice perspective; he won't be on the field in Arizona tomorrow, but could be ready by Sunday. He's been on the injury report for a couple of weeks now with a hip pointer, and you can add the chest injury suffered Sunday to his growing list of maladies.
Finally, there's the case of defensive end Mark Anderson, who injured a knee against San Francisco and had an MRI on Monday to determine the extent of his injury. (There's been no word as of yet on the precise severity.) It's therefore not yet known whether or not he'll be available to practice this week, much less play; if he's shelved, Chris Kelsay and Kyle Moore will likely split reps playing alongside Mario Williams.