Chandler was injured on the Bills' second play from scrimmage in yesterday's 24-10 loss to the Miami Dolphins. After hauling in what turned out to be a 25-yard catch and run, Chandler was hurt on the ensuing tackle. He was removed from the field of play, ruled out of a return to action almost immediately, and now will miss the team's season finale next week against the New York Jets.
ESPN's Adam Schefter tweets that Chandler's injury is a torn ACL; that'll likely require surgery, which may impact his early availability next summer. (That's obviously just speculation on our part.) Buffalo has yet to fill Chandler's vacated spot on the active roster, as well; it's probable that they'll sign a tight end to play a few snaps in next week's finale, particularly if Dorin Dickerson can't go.
Chandler, who signed a two-year contract last March, set career highs in receptions (43) and yards (571) this season, while matching his 2011 output with six touchdowns. Barring something unusual happening, he'll likely return as the team's starting tight end next season regardless of whatever organizational changes are forthcoming.