Spiller, who has been battling an ankle injury for about a month, worked out prior to the game but appeared very limited, according to reporters on hand. Fred Jackson will replace Spiller in the starting lineup, Tashard Choice will see an increased workload today, and rookie runner Ronnie Wingo will make his NFL debut with Spiller sidelined.
Lawson has an injured hamstring, and was a longshot from the moment that head coach Doug Marrone declared that Lawson had suffered a setback in his rehab on Thursday. He'll be replaced in the starting lineup by Jerry Hughes, and it seems more likely than not that another depth player - possibly Nigel Bradham, but perhaps someone else - will see more work, as well.
EJ Manuel is the only other injured Bill on this week's inactive list. The team has four healthy scratches: quarterback Matt Flynn (Jeff Tuel will serve as the backup once again), guard Antoine McClain, linebacker Ty Powell and cornerback Justin Rogers. McClain, Powell and Rogers have all been healthy scratches for three straight weeks, tying them for the team lead in that category with tight end Chris Gragg (who is active today).
On New Orleans' side of the equation, tight end Jimmy Graham is active, but is also expected to be limited by the foot injury that kept him out of practice most of this week. Three more key Saints will play: receiver Lance Moore, tackle Zach Strief and defensive lineman Cameron Jordan. Their most notable inactive is safety Roman Harper, who will be replaced in the starting lineup by rookie first-round pick Kenny Vaccaro.