New England, at 11-4, has already clinched a division crown and a playoff berth. They still have a shot at clinching home-field advantage throughout the playoffs, however, and can do so by beating Buffalo and the Denver Broncos (who kick off in Oakland at 4:25, as well) losing. The Patriots can also clinch the No. 2 seed in the conference with a win, or with losses or ties by both the Cincinnati Bengals (1PM versus Baltimore) and Indianapolis Colts (1PM versus Jacksonville).
The Bills, currently in last place in the division at 6-9, have won two straight games overall, and two straight in AFC East games. They'll look to close their 2013 campaign with a third straight win, which would avenge a two-point loss to New England at home in Week 1.