It's been 14 years since the Bills beat the Pats in the 2nd game---Flutie was the QB and it was the last playoff year. Will that come to an end this Sunday, especially if Manuel is the starter (and given that he's been bad on the road)? Looking at these stats, it doesn't look promising.
"To add it all up, the Patriots have outscored the Bills 381 – 130 (251 point difference) in the second divisional matchup since 2000. Take away the two games Brady did not play in against the Bills, the Patriots outscored the Bills 355 – 120 (235 point difference). In the 26 games played since 2000, the Patriots have outscored the Bills 728 – 372 (a 356 point difference). In the words of the late Ronnie James Dio: "LOOK OUT!" By looking at the scores, it's painfully obvious that the Bills have played better against the Patriots in their first divisional matchup of the year. What also confirms that even further, is that the Bills are 3-10 against the Patriots in the first divisional matchup of the year, vice 0-13 in their second divisional matchup of the year. The last time the Bills beat the Patriots in their second divisional matchup of the year, was on December 26, 1999, when the Bills (led by Doug Flutie) defeated the Patriots (led by Drew Bledsoe) 13-10 in overtime."