| Pick | Team | Player | Pos. | College | Drafter | |
| 33 | Oakland Raiders | Zach Miller | TE | Arizona St. | Saint | |
| 34 | Detroit Lions | Marcus McCauley | CB | Fresno State | Sean Yuille | |
| 35 | Tampa Bay Buccaneers | Buster Davis | LB | Florida State | JScott | |
| 36 | Cleveland Browns | Ryan Kalil | C | USC | ChrisPokorny | |
| 37 | Chicago Bears | Michael Griffin | S | Texas | WCG | |
| 38 | Arizona Cardinals | Brandon Meriweather | S | Miami (FL) | Jeff G | |
| 39 | Atlanta Falcons | Tony Ugoh | OT | Arkansas | Dave the Falconer | |
| 40 | Miami Dolphins | Arron Sears | OL | Tennessee | Phinatic | |
| 41 | Minnesota Vikings | Anthony Gonzalez | WR | Ohio State | Gonzo | |
| 42 | San Francisco 49ers | Sidney Rice | WR | South Carolina | Fooch | |
| 43 | Buffalo Bills | Antonio Pittman | RB | Ohio State | Brian G | |
| 44 | Atlanta Falcons | Charles Johnson | DE | Georgia | Dave the Falconer | |
| 45 | Carolina Panthers | Brandon Siler | LB | Florida | Jaxon | |
| 46 | Pittsburgh Steelers | Anthony Spencer | DE | Purdue | Blitzburgh | |
| 47 | Green Bay Packers | Tanard Jackson | CB | Syracuse | Brandon | |
| 48 | Jacksonville Jaguars | Tim Crowder | DE | Texas | River City Rage | |
| 49 | Cincinnati Bengals | Jon Beason | LB | Miami (FL) | Kirkendall | |
| 50 | Tennessee Titans | Josh Wilson | CB | Maryland | Jimmy | |
| 51 | New York Giants | Eric Wright | CB | UNLV | ETVal | |
| 52 | St. Louis Rams | Craig Davis | WR | LSU | VanRam | |
| 53 | Dallas Cowboys | Steve Smith | WR | USC | Grizz | |
| 54 | Kansas City Chiefs | Doug Free | OT | N. Illinois | Chris | |
| 55 | Seattle Seahawks | Michael Bush | RB | Louisville | Shrug | |
| 56 | Houston Texans | Jonathan Wade | CB | Tennessee | Tim | |
| 57 | Philadelphia Eagles | Brian Leonard | FB | Rutgers | JasonB | |
| 58 | New Orleans Saints | Rufus Alexander | LB | Oklahoma | Geaux Tigers | |
| 59 | New York Jets | LaMarr Woodley | DE | Michigan | nynix34 | |
| 60 | Miami Dolphins | Aundrae Allison | WR | E. Carolina | Phinatic | |
| 61 | Baltimore Ravens | Quentin Moses | DE | Georgia | SB Nation | |
| 62 | San Diego Chargers | Aaron Rouse | S | Virginia Tech | SB Nation | |
| 63 | New York Jets | Daymeion Hughes | CB | California | nynix34 | |
| 64 | Detroit Lions | David Harris | LB | Michigan | Sean Yuille | |
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