Marcus Stroud did not practice all week with a knee injury and has been ruled out, according to BuffaloBills.com. This could potentially leave the Bills with just two healthy defensive tackles on Sunday. Also ruled out were tackle Demetrius Bell (knee), linebacker Keith Ellison (thigh) and cornerback Ashton Youboty (ankle).
Stroud's absence is of critical importance. The Bills have the NFL's worst run defense, and they're about to take on the NFL's fifth-leading rusher in Maurice Jones-Drew without their most proven run defender. Exacerbating that issue is the fact that fellow defensive tackle Kyle Williams is on the injury report as well, listed as questionable with a knee injury that has caused him to miss Buffalo's last two games.
Spencer Johnson will start in Stroud's place, and if Williams can't go, John McCargo will make his first start of the season as well. Converted safety Bryan Scott will make a second straight start at outside linebacker in place of Ellison. Rookie guard Andy Levitre will flip out to left tackle in place of Bell, with veteran Seth McKinney getting the nod in Levitre's left guard spot.
Joining Williams as questionable for Sunday are receiver James Hardy (groin), cornerback Terrence McGee (knee) and rookie free safety Jairus Byrd (groin). McGee and Byrd were both limited in practice on Friday. With Donte Whitner returning to the lineup (he's not listed on the injury report and practiced all week), George Wilson would start at safety if Byrd can't go. If McGee cannot play, the Bills will dress just three healthy cornerbacks in Jacksonville (Drayton Florence, Reggie Corner and Ellis Lankster).
Meanwhile, Jacksonville will be missing one key defensive starter (cornerback Rashean Mathis) and is likely to be without another (middle linebacker Justin Durant is doubtful).