Hurricane Katrina hit New Orleans on August 29, 2005, submerging most of the city in water when the levees failed. With the Superdome damaged (see picture) and full of refugees, the Saints were forced to find other accommodations. Their first "home game" of the year came in the Meadowlands, as the team played the New York Giants with the money raised going to relief efforts.
The Saints made plans to split their home games between the city in south-central Texas and LSU's Tiger Stadium. The Bills were the first of three teams to face the Saints in the Alamodome, and became the Saints' only victory as a "home team" all season.
The Bills opened the scoring with a one-yard Willis McGahee touchdown, but four John Carney field goals and a four-yard Aaron Brooks touchdown run were enough for the weary road warriors to top the struggling Bills. Buffalo barely eclipsed 100 yards passing between J.P. Losman and Kelly Holcomb, and were penalized 12 times on the day. Deuce McAllister rushed for 130 yards in the winning effort.
After the win, the Saints were 2-2, but losing streaks of six and five games awaited them down the stretch, and they finished with a 3-13 record, costing head coach (and former Bills linebacker) Jim Haslett his job. Buffalo fell to 1-3 and ended the season 5-11. Head coach Mike Mularkey resigned after the season when GM Tom Donahoe was fired and replaced by Marv Levy.