In years past, one of the biggest questions surrounding the Buffalo Bills in the pre-season has been whether or not the team's starters would see enough playing time to adequately prepare for the regular season. They're getting a lot of work to this point under new head coach Chan Gailey; the team's offensive and defensive starters both played roughly a quarter and a half in last week's loss to Washington, and BuffaloBills.com reports that the starters will see slightly more time than that tonight against Indianapolis.
Both units saw roughly 20 snaps in D.C.; we all know how well each unit played in that particular game. There's an outside chance that each first-team unit could play the majority of the first half tonight, though it's also likely that returned starters like Demetrius Bell, Eric Wood and Paul Posluszny - who are expected to see playing time - will not see as many snaps as their fellow starters.
C.J. Spiller will get the start at running back with both Fred Jackson and Marshawn Lynch injured. Bell and Wood are likely to start at left tackle and right guard, respectively. If Cornell Green can't go, Jamon Meredith will likely take his spot on the right side. George Wilson will get the start at free safety in lieu of Jairus Byrd, who is out indefinitely after groin surgery.