It may not carry great significance; then again, it might. The Buffalo Bills have listed rookie C.J. Spiller at the top of their running back depth chart in their game release for Sunday's Week 1 matchup against Miami - which will also be Spiller's NFL debut.
As BuffaloBills.com notes, the depth chart is deemed "unofficial" by the club. Furthermore, veterans Fred Jackson and Marshawn Lynch are both listed as second-teamers; Jackson may only be there due to his ongoing recovery from a preseason hand injury. We've always known that Spiller's role would be significant - in fact, it's looking likely that he'll be the focal point of the offense - but "starter" was not a term we ever really applied to the electric rookie.
Spiller is also the first-team kick returner - Jackson and Lynch show up there, too, along with Leodis McKelvin and Donald Jones - and the backup punt returner (Roscoe Parrish).
In the end, this probably doesn't mean much. Spiller was always going to play a lot, and his being atop an unofficial depth chart shouldn't diminish the roles that Jackson and Lynch are likely to get, either. Still, the Bills aren't being shy with Spiller; he's front and center in virtually every way imaginable. Just add this one to the growing list.