Bills vs. 49ers: Game Time, TV Schedule, Odds & More

The Buffalo Bills head out west looking for their treasure - a win to get that ugly taste out of their mouth. Unfortunately, the San Francisco 49ers aren't a cupcake team and will provide a steep task as the Bills try to win on the West Coast for the first time since 2004.

Fun fact: this is Buffalo's latest kickoff time since a Thursday night game in Week 13 of the 2009 season. The NFL pushed back the late start times from 4:15 to 4:25 Eastern time beginning this season.

Buffalo Bills (2-2) at San Francisco 49ers (3-1)

• Game time: 4:25 PM ET
• Location: Candlestick Park, San Francisco, CA
  
• Television: CBS affiliates in most of Upstate NY, NW Pennsylvania, Arizona, and the West Coast
• Announcers: Kevin Harlan and Solomon Wilcots
• Radio: Buffalo Bills Radio Network, WGR 550 AM in Buffalo, WGR550.com streaming over the web
• Web: NFL Game Center
• Odds: 49ers by 10