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NFL Week 10 Predictions: How About A Buffalo Bills Upset?

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The Bills have lost 17 of their last 18 games to the Patriots. Are there any Bills fans out there bold enough to predict a Bills win at Foxboro in Week 10?

Kevin Hoffman-US PRESSWIRE

Just as we do every week, here are our predictions for the next slate of NFL games. We'll save our Buffalo Bills prediction for last, and open with this question: are any of you bold enough to predict a Bills win over New England this weekend?

Colts 30, Jaguars 20: Andrew Luck is the real deal. The Jaguars... are not.

Ravens 27, Raiders 20: Baltimore's not quite the same without a great defense, but they're certainly good enough to beat Oakland.

Broncos 31, Panthers 13: Peyton Manning is just hitting his stride. The Panthers are playing better of late, but it won't matter against Peyton.

Giants 28, Bengals 17: Cincinnati, in my book, is perhaps the most disappointing team in the NFL this season.

Dolphins 23, Titans 13: Who else wishes that the Bills could've played against Jake Locker in Week 7?

Lions 20, Vikings 17: Minnesota's come back to earth lately, and Detroit is starting to get it together a little bit offensively. This is a toss-up, but I like Detroit to get back into the conversation for real in the very good NFC North.

Falcons 27, Saints 24: New Orleans is a trendy pick this week, but I don't think they have enough defensively to end Atlanta's winning streak.

Buccaneers 31, Chargers 24: Doug Martin may not like "Muscle Hamster," but I kind of do. It's weird and catchy. He'll have another good day against a thoroughly mediocre Chargers team.

Seahawks 26, Jets 14: Seattle is excellent at home. The Jets are pretty average everywhere.

Cowboys 23, Eagles 20: It's still really hard for me to pick against Philadelphia, especially when they're playing a Cowboys team that is truly outstanding at beating themselves.

49ers 27, Rams 14: San Francisco has too much on both sides of the ball for a plucky Rams squad to handle.

Texans 21, Bears 19: I've said all season that the turnovers will stop coming for the Bears at some point. I think it'll be this week against the Texans. Whenever it happens, that Bears offense will really be put to the test.

Steelers 38, Chiefs 10: Well, at least I'll have a Monday night free to not watch football. This one'll be ugly.

Patriots 41, Bills 20: Yeah, I'm definitely not bold enough to predict a Bills win in New England. Goodness gracious, no. But I'll maintain something I've said this year: they have the ability to compete with any team in any stadium. Get it done, Buffalo.

Last Week: 11-3
NFL Prediction Record: 84-48
Bills Prediction Record: 5-3