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The Buffalo Bills have released 21 players and placed rookie offensive tackle Zebrie Sanders on Injured Reserve this evening, meaning that they have pared their roster down to 53 players. By no means is the roster completely settled - the team has made last-minute adjustments to the roster after the cut-down deadline in each of the last two years - but for now, these are the men we'll see taking on the New York Jets in ten days. The full depth chart is after the jump.
| Pos. | # | Starter | # | Backup | # | Reserve |
| WR | 13 | Stevie Johnson | 11 | T.J. Graham* | ||
| LT | 77 | Cordy Glenn* | 75 | Chris Hairston | ||
| LG | 67 | Andy Levitre | ||||
| C | 70 | Eric Wood | 74 | Colin Brown | ||
| RG | 60 | Kraig Urbik | 76 | Chad Rinehart | ||
| RT | 79 | Erik Pears | 71 | Sam Young | ||
| TE | 84 | Scott Chandler | 85 | Lee Smith | ||
| WR | 19 | Donald Jones | 86 | David Nelson | 16 | Brad Smith |
| QB | 14 | Ryan Fitzpatrick | 4 | Tyler Thigpen | 7 | Tarvaris Jackson |
| RB | 22 | Fred Jackson | 28 | C.J. Spiller | 29 | Tashard Choice |
| FB | 38 | Corey McIntyre | 42 | Dorin Dickerson | ||
| LE | 94 | Mario Williams | 90 | Chris Kelsay | ||
| DT | 99 | Marcell Dareus | 91 | Spencer Johnson | ||
| DT | 95 | Kyle Williams | 92 | Alex Carrington | ||
| RE | 93 | Mark Anderson | 54 | Kyle Moore | ||
| SLB | 52 | Arthur Moats | 53 | Nigel Bradham* | 51 | Chris White |
| MLB | 55 | Kelvin Sheppard | 58 | Kirk Morrison | ||
| WLB | 50 | Nick Barnett | 43 | Bryan Scott | ||
| LCB | 23 | Aaron Williams | 24 | Terrence McGee | 26 | Justin Rogers |
| SS | 37 | George Wilson | 36 | Delano Howell* | ||
| FS | 31 | Jairus Byrd | 25 | Da'Norris Searcy | ||
| RCB | 27 | Stephon Gilmore* | 21 | Leodis McKelvin | 33 | Ron Brooks* |
| K | 9 | Rian Lindell | 3 | John Potter* | ||
| P | 8 | Brian Moorman | ||||
| LS | 65 | Garrison Sanborn |