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Week 12 of the NFL schedule began last night with a Thursday Night Football matchup between the Atlanta Falcons and the New Orleans Saints. As is our weekly custom, the Buffalo Rumblings Podcast dudes have submitted their Week 12 picks. Who do you like this weekend?
| Matchup | Matt (104-58) | Brendan (101-61) | Brian (100-62) |
| Saints (8-2) at Falcons (2-8) | Saints | Saints | Saints |
| Jets (5-5) at Ravens (4-6) | Ravens | Jets | Ravens |
| Steelers (4-6) at Browns (4-6) | Steelers | Browns | Browns |
| Buccaneers (2-8) at Lions (6-4) | Lions | Lions | Lions |
| Vikings (2-8) at Packers (5-5) | Packers | Packers | Packers |
| Jaguars (1-9) at Texans (2-8) | Texans | Texans | Texans |
| Chargers (4-6) at Chiefs (9-1) | Chiefs | Chiefs | Chiefs |
| Panthers (7-3) at Dolphins (5-5) | Panthers | Panthers | Panthers |
| Bears (6-4) at Rams (4-6) | Bears | Rams | Bears |
| Colts (7-3) at Cardinals (6-4) | Colts | Colts | Colts |
| Titans (4-6) at Raiders (4-6) | Raiders | Raiders | Raiders |
| Cowboys (5-5) at Giants (4-6) | Giants | Cowboys | Giants |
| Broncos (9-1) at Patriots (7-3) | Broncos | Patriots | Broncos |
| 49ers (6-4) at Redskins (3-7) | 49ers | 49ers | 49ers |