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Week 10 of the NFL schedule begins tonight with a Thursday Night Football matchup between the Washington Redskins and the Minnesota Vikings. As is our weekly custom, the Buffalo Rumblings Podcast dudes have submitted their Week 10 picks. Who do you like this weekend?
| Matchup | Matt (86-47) | Brendan (85-48) | Brian (83-50) |
| Redskins (3-5) at Vikings (1-7) | Redskins | Vikings | Vikings |
| Seahawks (8-1) at Falcons (2-6) | Seahawks | Seahawks | Seahawks |
| Bengals (6-3) at Ravens (3-5) | Bengals | Bengals | Ravens |
| Lions (5-3) at Bears (5-3) | Lions | Bears | Lions |
| Eagles (4-5) at Packers (5-3) | Packers | Packers | Eagles |
| Rams (3-6) at Colts (6-2) | Colts | Colts | Colts |
| Raiders (3-5) at Giants (2-6) | Giants | Giants | Giants |
| Bills (3-6) at Steelers (2-6) | Bills | Bills | Bills |
| Jaguars (0-8) at Titans (4-4) | Titans | Titans | Titans |
| Panthers (5-3) at 49ers (6-2) | 49ers | 49ers | 49ers |
| Texans (2-6) at Cardinals (4-4) | Cardinals | Cardinals | Texans |
| Broncos (7-1) at Chargers (4-4) | Broncos | Broncos | Broncos |
| Cowboys (5-4) at Saints (6-2) | Saints | Saints | Saints |
| Dolphins (4-4) at Buccaneers (0-8) | Buccaneers | Buccaneers | Dolphins |