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Week 2 of the 2013 NFL season kicks off tonight when the New England Patriots (last week's Buffalo Bills opponent) take on the New York Jets (next week's Buffalo Bills opponent). As usual, Matt, Brendan and I have made our picks for the week. Who do you like this weekend?
| Matchup | Matt (10-6) | Brendan (9-7) | Brian (9-7) |
| Patriots (1-0) vs. Jets (1-0) | Patriots | Patriots | Patriots |
| Falcons (0-1) vs. Rams (1-0) | Falcons | Falcons | Falcons |
| Ravens (0-1) vs. Browns (0-1) | Ravens | Ravens | Ravens |
| Bills (0-1) vs. Panthers (0-1) | Bills | Panthers | Bills |
| Bears (1-0) vs. Vikings (0-1) | Bears | Bears | Bears |
| Packers (0-1) vs. Redskins (0-1) | Packers | Packers | Packers |
| Texans (1-0) vs. Titans (1-0) | Texans | Texans | Texans |
| Colts (1-0) vs. Dolphins (1-0) | Colts | Dolphins | Colts |
| Chiefs (1-0) vs. Cowboys (1-0) | Chiefs | Chiefs | Cowboys |
| Eagles (1-0) vs. Chargers (0-1) | Eagles | Eagles | Eagles |
| Cardinals (0-1) vs. Lions (1-0) | Lions | Lions | Lions |
| Buccaneers (0-1) vs. Saints (1-0) | Saints | Saints | Saints |
| Giants (0-1) vs. Broncos (1-0) | Broncos | Broncos | Broncos |
| Raiders (0-1) vs. Jaguars (0-1) | Raiders | Raiders | Raiders |
| Seahawks (1-0) vs. 49ers (1-0) | 49ers | 49ers | Seahawks |
| Bengals (0-1) vs. Steelers (0-1) | Bengals | Bengals | Bengals |