LeSean McCoy is officially doubtful for the upcoming home game against the New England Patriots, making it very likely that he'll miss his first game of the year at a time when the team can least afford to lose him.
McCoy was only questionable when the Bills traveled to Miami to face the Dolphins last week, but his hamstring injury forced him to leave the game after an ineffective three quarters. Mike Gillislee, who is listed as questionable with a foot injury, is expected to play and carry the load. Reggie Bush, he of the garbage time touchdown last week, and Jonathan Williams are available to shoulder some carries as well.
Two players who won't play this week are wide receiver Marquise Goodwin and safety Aaron Williams. Goodwin suffered a concussion late in the loss to the Dolphins and hasn't been cleared, a move that seemed likely enough to prompt the team to promote receiver Ed Eagan from the practice squad to the active roster this week.
Williams, on the other hand, is a likely candidate for IR after his neck injury at the hands (or rather, shoulder) of Jarvis Landry. The Bills have a deep stable of safeties behind Williams, although none can match his tackling and ball skills.
One guy who should be ready to go, for the first time this season, is defensive tackle Marcell Dareus. After missing the first four games of the year due to a suspension, he's missed the last three with a hamstring injury. He's listed as questionable, but all signs are that he'll make his season debut on Sunday, a much-needed boost for a team that was gashed again and again by Jay Ajayi last week.
Dareus' fill-in for the last seven weeks, Corbin Bryant, is listed as questionable with a shoulder injury. He should be able to play but will serve as a depth player along with Jerel Worthy and Leger Douzable.
Injury-report mainstay Cordy Glenn is questionable with his ongoing ankle injury. Fellow offensive tackle Seantrel Henderson is going to be a full-go for the first time this season, however, and Cyrus Kouandjio is also at full strength, so if Glenn has to sit it shouldn't be an issue.
Receiver Robert Woods has been back to practice all week in a limited capacity with a foot injury. He spent most of last week in a walking boot, but was able to shed that by Sunday, so his outlook for is promising. Tight end Charles Clay is also questionable, as usual, with a knee injury. Assuming he's going through the usual flow by sitting Wednesday and running limited the next two days, he should be good to go as well.
A couple of linebackers, Jerry Hughes (hand) and Lerentee McCray (knee), are both questionable this week. Hughes has been limited all week, so he should be fine. McCray sat out Wednesday's practice, but even if he sits his role as a backup edge-rusher can be filled by Shaq Lawson.
Finally, starting guard John Miller is questionable with a shoulder injury. He's practiced all week, so he should be fine, but if he has to sit look for Ryan Groy to fill his spot in the starting lineup.