Charles Clay and Ramon Humber are both still recovering from injuries and were ruled out on Friday. Nick O’Leary will start at tight end in Clay’s place, while Matt Milano will make his second start of the year at linebacker for Humber.
Cedric Thornton has been prominently featured on the defensive line all year, but he’ll take a seat today in favor of Adolphus Washington and Jerel Worthy. Marcell Dareus could also see his playing time increase a bit.
Seantrel Henderson was recently added to the active roster after missing the first five games of the year as part of a roll-over of last year’s 10-game suspension, but he won’t be returning to the active roster today. Jordan Mills will likely remain as the starter at right tackle, with either Cordy Glenn or Dion Dawkins starting at left tackle. Conor McDermott had been relegated to special teams when active, so his snaps will likely go to one of the reserve linemen.
Miller will be inactive for the second straight game, and Vlad Ducasse will start in his place. Neither player has been all that good in 2017, but the offensive staff is going to continue to give Ducasse a shot to establish himself on the line.
Matthews’ return to the lineup was reported earlier in the day, but with Clay inactive it seems that newly-signed Deonte Thompson will also be active with the Bills for the first time since appearing in two plays at the end of the team’s Week 17 win over the New England Patriots in 2014.