Lynch was suspended for one game after pushing a referee in last Thursday night's game. Lynch appealed his suspension but it was upheld by the league on Tuesday.
This would have been the running back's first game in Buffalo since he was traded during the 2010 season.
Without Lynch, the Raiders' running attack will take a hit. The team's leading rusher outside of Lynch is Jalen Richard, who has only carried the ball 35 times this season, but is averaging 5.5 yards per carry for a total of 158. He has also scored one touchdown this season. Behind Richard, Oakland has second-year back DeAndre Washington, who has 23 carries for 53 yards on the season.
Richard actually has a higher yards per carry than Lynch, but has significantly less carries. On Sunday, we’ll find out if he can keep his production that high as a feature back.