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Bills vs. Chargers: Buffalo opens as huge west coast favorites for Week 16

If you’re looking to wager on the outcome of Bills vs. Chargers, now’s the time to get in on the action with DraftKings Sportsbook!

NFL: Los Angeles Chargers at Buffalo Bills Rich Barnes-USA TODAY Sports

Are you ready for some football? The 8-6 Buffalo Bills are hitting the road to take on the reeling 5-9 Los Angeles Chargers, and there’s a lot at stake for both teams. The Bills open as 13.5 point favorites, with the over/under set at 42.5. The Moneyline has Buffalo at -950 and the Chargers at +625. But what do all of these lines actually mean?

Let’s break it down. The point spread, in this case 13.5 points, means that the Bills are favored to win by at least that margin. So, if you place a bet on the Bills, they would need to win by 14 points or more for you to win your bet. The over/under of 42.5 reflects the total number of points that oddsmakers believe will be scored in the game. You can bet on whether the actual total will be over or under that number. The Moneyline odds of -950 for the Bills and +625 for the Chargers represent the payouts on a straight-up win bet. A negative number means you’d have to bet that much to win $100, while a positive number means you’d win that much on a $100 bet.

Now that we’ve got the technical stuff out of the way, let’s dive into the matchup. The Chargers are coming off a humiliating 63-21 loss to the Las Vegas Raiders, and their star quarterback, Justin Herbert, has been sidelined for the rest of the season with an injury to his throwing hand. This leaves the Chargers in a tough spot as they try to regroup and salvage the remainder of the season. With their playoff hopes dashed, the Chargers will have to embrace the role of trying to play spoiler against the Bills.

On the other hand, Buffalo’s riding high after a convincing win over the Dallas Cowboys. They looked dominant and in control throughout the game, and with the AFC East race with the Miami Dolphins heating up, every win is crucial. Quarterback Josh Allen has been playing at a high level, and the Bills’ defense has been solid recently in order to save the season. They’ll be looking to continue their momentum against the struggling Chargers.

Looking ahead to the game, while the Bills are heavy favorites, anything can happen in the NFL. The Chargers may be down, but they’re not out, and they’ll be looking to bounce back in front of their home crowd. Can Buffalo continue its winning ways, or will the Chargers pull off an upset?

Do you think the Bills will cover the spread and come out on top, or do you see the Chargers pulling off a surprise win? And remember, in the NFL, expect the unexpected!

Take your wagers to the next level — join the in-game fun with DraftKings Sportsbook, where your best bets are always up to date!