Buffalo pasted Indianapolis in Orchard Park in Week 1, but in the three games since, the reverse has been true. The undefeated New England Patriots opened up a 37-13 lead in what was ultimately a 40-32 victory in Week 2; the New York Giants took a 16-3 lead and cruised to a 24-10 win; and the undefeated Cincinnati Bengals used a dominant third quarter to take a 34-14 lead that ultimately ended in a 34-21 final score.
The Bills have lost three straight games in Orchard Park for the first time since the 2011 season, a year that they began with a 5-2 stretch, only to finish 7-9. They dropped games to the Jets (27-11, Week 9), Tennessee (23-17, Week 13), and Miami (30-23, Week 15) in that stretch.
If the Bills can't end their home losing streak against a Miami organization that has lost three straight games in Buffalo, it'll be their first four-game home skid since 2008, when the Bills were led by Dick Jauron, Trent Edwards, and J.P. Losman and lost consecutive home games to the Jets (26-17, Week 9), Cleveland (29-27, Week 11 on Sunday Night Football), San Francisco (10-3, Week 13), and New England (13-0, Week 17).