Williams, who missed a Week 6 loss to New England with neck and wrist injuries, re-aggravated the neck ailment in Week 7 against Minnesota. He was a limited practice participant all three days this week, and has been officially listed as questionable. If he can't play, it's likely that Corey Graham, Duke Williams, and Da'Norris Searcy would split up the team's safety reps against the run-heavy Jets.
Also listed as questionable: reserve receiver and special teams ace Marcus Easley. He's working back from a knee injury that caused him to miss each of the last four weeks, and like Williams was a limited practice participant all week. His return would be highly beneficial to a Bills special teams outfit that will be without another top coverage player, linebacker Ty Powell, who is out with an ankle injury.
Joining Powell on the inactive list on Sunday: running back Fred Jackson (groin) and, in all likelihood, wide receiver Marquise Goodwin (hamstring). Goodwin's absence (he's doubtful) will help Mike Williams' playing time cause, especially if Easley can't go, while Jackson will be replaced at the tailback position by a combination of Anthony Dixon and Bryce Brown.
Four players are listed as probable: wide receiver Sammy Watkins (groin), defensive end Mario Williams (thumb), and linebacker Brandon Spikes (ribs), and cornerback Ron Brooks. The three starters were full practice participants this week, while Brooks tweaked his groin on Friday.