Albert Breer of NFL.com was the first to say as much on Thursday morning, saying that there is a "decent chance" that Jackson won't play. Tim Graham of The Buffalo News is taking it a step further with his mid-day report on the matter.
I'm told Bills RB Fred Jackson almost certainly won't play tonight because of groin injury. Recovery from Sunday has taken too long.— Tim Graham (@ByTimGraham) November 13, 2014
Jackson injured his groin in a Week 7 win over Minnesota. He did not play the following week in a win over New York, but returned in Sunday's loss to Kansas City, playing 27 out of 73 snaps in a situational role while still less than 100 percent.
On a short work week, Jackson is apparently not healthy enough to suit up four days removed from his last game - though, let's be honest, we're talking about Fred Jackson, here. Would it really be shocking if he ended up suiting up?
If Jackson does not end up playing tonight, the Bills will roll with Anthony Dixon and the emerging Bryce Brown as their running backs. The team also has veteran Phillip Tanner in reserve, though he has yet to be active in his two games with the Bills since Jackson's injury.