- FB Frank Summers (healthy scratch)
- WR Mike Williams (calf)
- TE Chris Gragg (knee)
- OT Cyrus Kouandjio (healthy scratch)
- DE Jarius Wynn (knee)
- LB Randell Johnson (healthy scratch)
- S Bacarri Rambo (healthy scratch)
Williams, Gragg, and Wynn had previously been ruled out on Friday, so their unavailability was already known. It was also safely assumed for Kouandjio and Johnson; Kouandjio has now been inactive for 12 out of 13 weeks this season, while Johnson is a healthy scratch for a fifth consecutive week.
Rambo, a reserve safety and special teams player, was on the injury report with a hamstring injury, but was also listed as probable after practicing all week, so we're considering him a healthy scratch. Summers, who is a bit of a fan favorite and the Bills' only fullback, is a healthy scratch for a third straight game. He has not played more than a dozen snaps in a game since a Week 7 home win over Minnesota.