Marcus Easley, dealing with a sprained MCL, is expected to miss at least a month of action, and has been ruled out for this week. Marquise Goodwin suffered a concussion in practice this week, and is listed as doubtful. With six receivers on the roster, the Bills look like they'll be down to four in Houston, with Chris Hogan perhaps seeing offensive snaps for the first time this season, as well as increased importance on special teams.
Sammy Watkins (ribs) and Robert Woods (ankle) are both on the injury report, as well, but they've been there for two weeks now, and both played nearly every snap in last week's loss to San Diego.
The Bills are also likely going to have a new starting left guard, as Chris Williams (back) is doubtful to play. Doug Marrone told reporters that both Cyril Richardson and Kraig Urbik may rotate there, but Richardson saw first-team work at the position all three days of practice (as well as during the preseason), so expect the fifth-round rookie to start.
EJ Manuel (abdomen), C.J. Spiller (chest), Ron Brooks (illness), and Da'Norris Searcy (ankle) are all listed as probable - and they are joined there by veteran linebacker Keith Rivers, who has missed each of the last two games with a groin injury. It will be interesting to see how Rivers' return to the lineup affects the playing time of rookie Preston Brown, who has not yet missed a defensive snap this season.
Along with Easley, rookie linebacker Randell Johnson (knee) is listed as out.