Watkins missed parts of three games during the exhibition schedule with a rib injury, and the Bills' refusal to comment on his availability throughout the week led to some concern. It appears, however, that Watkins is ready to make his NFL debut in two days, though how close he is to 100 percent could affect how often he comes off the field.
Starting linebacker Brandon Spikes is also listed as questionable with a knee injury; it does not appear that the brief period in which he left practice on Thursday will limit his availability against Chicago's excellent offense. Fellow linebacker Randell Johnson (ankle) is also listed as probable, which is good news for the team's body count at an already-thin position.
Stephon Gilmore (groin) is listed as questionable, but all indications are that he'll be ready to play despite being limited throughout the work week. Anthony Dixon (hamstring) is also listed as questionable; if he can't play, the Bills will be fine at running back, but could miss him dearly on special teams.
Two players are listed as doubtful, and are therefore unlikely to play: blocking tight end Lee Smith (toe) and reserve safety Jonathan Meeks (neck). Smith did not practice all week, while Meeks was mostly limited.