You've probably heard of them: running back LeSean McCoy (hamstring), wide receiver Sammy Watkins (calf), guard John Miller (groin), and safety Aaron Williams (neck) are the four starters that won't play, and they'll be joined by wide receiver Marquise Goodwin (ribs), as well.
McCoy will be replaced in the starting lineup by rookie Karlos Williams, who is averaging 7.8 yards per carry and has three touchdowns so far this season. Boobie Dixon will back him up, and the Bills on Friday elevated Cierre Wood to the active roster (releasing Andre Fluellen in the process) so that he can serve as the third back while McCoy is sidelined.
Watkins' absence will mean that Robert Woods will start in his place, and that slot receiver Chris Hogan will see an uptick in playing time, as well.
Miller, who like McCoy and Watkins missed most of last week's win in Miami, will be replaced at right guard by veteran Kraig Urbik. Second-year pro Gabe Ikard will also dress for the first time this season as the top reserve at both guard and center.
Williams, who missed last week's game, will once again be replaced in the starting lineup by Bacarri Rambo.
The Giants enter this game a bit banged up, as well, with wide receiver Victor Cruz (calf) and defensive end Robert Ayers (hamstring) headlining their injury report this week. Both starters have been ruled out.