- Twice the Bills had long touchdowns called back due to penalty.
- They were called for 17 penalties total, the third-most in team history.
- They had more penalties (17) that first downs (14).
The Bills were able to make it a one-score game halfway through the fourth quarter but on the Giants next possession, Rashad Jennings took a third down stop and made multiple defenders miss on his way to a 50-yard score.
Buffalo also was snake-bitten by turnovers. A Tyrod Taylor pass was intercepted on an extremely athletic play early in the first half and right after the Giants made it a two-score game in the fourth with Buffalo mounting a comeback, Robert Woods lost the ball fighting for extra yardage.