For the Bills, three starters were ruled out on Friday: running back LeSean McCoy (knee), tight end Charles Clay (back), and linebacker Nigel Bradham (ankle). None of those three players practiced all week. Meanwhile, cornerback Ronald Darby (groin) returned to practice on Friday after missing on Thursday, but head coach Rex Ryan told reporters that Darby didn't do much yesterday, making his questionable status seem perhaps a bit optimistic.
If Darby can't play, there's at least some reciprocating bad news coming out of Dallas, where star receiver Dez Bryant is listed as doubtful with a foot injury, and slot receiver Cole Beasley is questionable with a knee ailment. Beasley may play, but not having Bryant will be a big loss for an offense already riddled by injury - and it'll make the job of new starting quarterback Kellen Moore significantly more difficult.
Also of note for Dallas: starting cornerback Morris Claiborne is listed as questionable with a hamstring injury.