The Buffalo Bills had a rough go during the preseason with injuries to their top five wide receivers and top four running backs. Thankfully, those injuries have healed, where the vast majority of them will play against the Indianapolis Colts.
Here is the full list of inactives: quarterback EJ Manuel, running back Bryce Brown, linebacker Tony Steward, center Gabe Ikard, receiver Marquise Goodwin, tight end Chris Gragg, and defensive lineman Andre Fluellen.
Starting running back LeSean McCoy missed all but the first game of the preseason game with a hamstring injury that still isn't 100 percent. He's expected to take the majority of snaps, but will be spelled with other returning-from-injury backs Karlos Williams and Boobie Dixon. Sammy Watkins, Robert Woods, and Percy Harvin will all be full go for the Bills after fully practicing this week; they all sat during the final weeks of the preseason. Goodwin is the only player from the offensive depth chart still dealing with injury, and will miss today's game.
On defense, the Bills placed backup linebacker Ty Powell on injured reserve and his backup, Steward, will be out against Indianapolis. Undrafted free agent A.J. Tarpley will be the primary backup inside. Leodis McKelvin will be out for at last the next two months with his leg injury, so Ronald Darby will start in his NFL debut. (McKelvin is on the Reserve/Non-Football Injury list so he is not listed as Inactive.)