Buffalo Bills schedule 2016 highlighted by two prime-time games

The Buffalo Bills' 2016 regular season schedule has been officially released, and Rex Ryan and company will be appearing on prime-time television for two of their games next season.

Their first night game will occur in Week 2, on September 15, when they host the Jets on the first Thursday Night Football matchup of the season (the season-opening Thursday night game is not part of that package). In two matchups against his former team last season, Ryan's Bills swept the Jets, winning both games by a final score of 22-17 - including a Thursday Night Football game at MetLife Stadium in November. This year, the rematch will occur at The Ralph, and it doubles as the team's home opener, which is sure to be memorable. Keep in mind that this will also be a "Color Rush" matchup, so the Bills will likely be donning their all-red digs - unless the league decides to do something about that whole red-green color blind thing.

On November 7, the Bills will take on the Seattle Seahawks on Monday Night Football. It's their second straight season with a Monday night appearance, and both were on the road; the Bills lost, 20-13, in New England last November, one week after their Thursday night win in New Jersey.

The trip to Seattle is one of three visits to the Pacific time zone that the Bills will make next season, and as the team requested, none of them will be back-to-back. Their first trip to Los Angeles in over two decades takes place on October 9, and is sandwiched by a short road trip to New England and a home game. The Seattle prime time game is surrounded by a home game and a bye week, and a later trip to Oakland is also sandwiched by home games.

To open the season, the Bills will travel to take on another of Ryan's former teams, the Baltimore Ravens, in a game that will also feature two starting quarterbacks that double as former teammates in Joe Flacco and Tyrod Taylor. That's the Week 1 matchup you'll be thinking about for the next five months.

One other note on a popular annual gripe about the Bills' schedule: Buffalo will not be playing any teams this season that are coming off of bye weeks. Two opponents will be coming off of Thursday night games (yes, New England is one of them, in Week 4; San Francisco in Week 6 is the other), and a third will be coming off of a Saturday game (Miami in Week 16), but otherwise, that particular argument is completely irrelevant this season.

Here's the Bills' full 2016 regular season schedule. Which contests stick out most to you?